long-term effects of betamethasone on epididymal tissue, epididymal sperm counts and fertility in male mice
Authors
abstract
recent studies show that synthetic glucocorticoids alter testicular homeostasis, in this regard, the influence of betamethasone as a glucocorticoid widely used on histological changes, epididymal sperm counts and fertility was explored in male mice. the study sample (50 mice) was allocated to 3 treatment groups, placebo and a control group. control group was no injected. only normal saline was given to the placebo group and betamethasone (0.1, 0.5 and 1 mg/kg) was injected to the treatment group in peritoneum for 20 days (every other day). after treatment periods, two mice from each group were selected to measure fertility and each male with two females mice were kept for 15 days. after two weeks, the female mice were sedated and the number of embryos in the uterine horn was counted. however, epididymal sperm was counted in others mice by preparation epididymal suspension. the data analysis was done in spss through the duncan's multiple ranges test. evaluation of epididymal sections under the microscope showed difference between the group treated in epididymal tissue sections and the control group. this means that the amount of spermatozoa in treated groups with betamethasone was lower than in the control group. epididymal sperm and the fertility rate in all doses of betamethasone significantly decreased compared with the control group. however, increasing the dose of betamethasone fertility rate also non-significantly decreased. it seems that glucocorticoids like the betamethasone affect testicular function and spermatogenesis causes reduced fertility and have adverse effects on male reproduction.
similar resources
P-20: Long-Term Effects of Dexamethasone on Rate of Epididymal Sperm and Fertility in Male Mice
Background: Today, one of the world's most complex issues of fertility - infertility is becoming a concern. Under such conditions, evaluation mechanism and factors affecting fertility to control problem appears to be necessary and reasonable. Among these side effects of drugs should not be neglected. This study was designed to investigate the possible effects of Dexamethasone on rate of ep...
full textThe effects of long-term administration of tramadol on epididymal sperm quality and testicular tissue in mice
Objective- The objective of the present work was to investigate the effects of tramadol administration on sperm quality and testicular tissue in mice. Design- Experimental study Animal- Sixty-three mature male mice Procedures- Mice were randomly divided into three experimental groups (n=21) and the following treatments were intraperitoneally administered, 3 times a week, for 6 weeks: Control...
full textthe effects of keyword and context methods on pronunciation and receptive/ productive vocabulary of low-intermediate iranian efl learners: short-term and long-term memory in focus
از گذشته تا کنون، تحقیقات بسیاری صورت گرفته است که همگی به گونه ای بر مثمر ثمر بودن استفاده از استراتژی های یادگیری لغت در یک زبان بیگانه اذعان داشته اند. این تحقیق به بررسی تاثیر دو روش مختلف آموزش واژگان انگلیسی (کلیدی و بافتی) بر تلفظ و دانش لغوی فراگیران ایرانی زیر متوسط زبان انگلیسی و بر ماندگاری آن در حافظه می پردازد. به این منظور، تعداد شصت نفر از زبان آموزان ایرانی هشت تا چهارده ساله با...
15 صفحه اولLong-term regulation of male fertility by norethisterone enanthate 'epididymal' implants: effect on libido and fertility of rabbits.
Bilateral insertion of silastic capsules releasing 38-44 micrograms norethisterone enanthate/24 h into the epididymal fat-pads was found to induce complete azoospermia leading to infertility in adult male rabbits 8 weeks after insertion of the progestin implants. The treatment did not exert any inhibitory effects on the libido and sexual behaviour of the animals as judged by objective parameter...
full textCryopreservation and fertility of ejaculated and epididymal stallion sperm.
The cryopreservation of epididymal sperm is important to preserve genetic material from valuable deceased males. This study evaluated the viability of sperm samples from eight stallions under three conditions: (1) collected using an artificial vagina (EJ-0h), (2) recovered from the epididymal cauda immediately after orchiectomy (EP-0h), and (3) recovered from the epididymal cauda after 24h of s...
full textMy Resources
Save resource for easier access later
Journal title:
journal of chemical health risksجلد ۵، شماره ۴، صفحات ۰-۰
Keywords
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023